{"id":1829,"date":"2026-09-14T13:11:33","date_gmt":"2026-09-14T04:11:33","guid":{"rendered":"https:\/\/rhanews.co.kr\/?p=1829"},"modified":"2026-09-14T13:11:33","modified_gmt":"2026-09-14T04:11:33","slug":"%ea%b7%bc%ec%9c%a1%ec%9d%80-%eb%ac%b4%ea%b2%8c%eb%a5%bc-%eb%93%a4-%eb%95%8c-%eb%a7%9d%ea%b0%80%ec%a7%80%ea%b8%b0%eb%a7%8c-%ed%95%98%ec%a7%80-%ec%95%8a%eb%8a%94%eb%8b%a4-flnc","status":"publish","type":"post","link":"https:\/\/rhanews.co.kr\/?p=1829","title":{"rendered":"\uadfc\uc721\uc740 \ubb34\uac8c\ub97c \ub4e4 \ub54c \u2018\ub9dd\uac00\uc9c0\uae30\ub9cc\u2019 \ud558\uc9c0 \uc54a\ub294\ub2e4\u2026 FLNC\ubd80\ud130 BAG3\u00b7CASA\uae4c\uc9c0, \uae30\uacc4\uc801 \uc7a5\ub825\uc774 \uadfc\uc721\uc744 \uc7ac\uc815\ube44\ud558\ub294 \uacfc\uc815"},"content":{"rendered":"

<\/h3>\n

\"\"<\/h3>\n

\uc800\ud56d\uc6b4\ub3d9\uc73c\ub85c \ub2e8\ubc31\uc9c8\uc774 \ubcc0\ud615\ub418\uba74 \uc774\ub97c \uac10\uc9c0\ud558\uace0 \uace8\ub77c\ub0b4\ub294 \uc138\ud3ec \ub0b4 \ud488\uc9c8\uad00\ub9ac \uc2dc\uc2a4\ud15c \uc791\ub3d9<\/h3>\n

FLNC \uc190\uc0c1 \u2192 BAG3\u00b7HSPB8 \uc911\uc2ec CASA \u2192 \uc720\ube44\ud034\ud2f4 \ud45c\uc9c0 \u2192 SQSTM1 \u2192 \uc624\ud1a0\ud30c\uace0\uc880 \u2192 \ub9ac\uc18c\uc880 \ubd84\ud574 \u2192 \uc0c8\ub85c\uc6b4 \uad6c\uc870 \ub2e8\ubc31\uc9c8 \uad50\uccb4<\/h3>\n

\uc6e8\uc774\ud2b8\ud2b8\ub808\uc774\ub2dd\uc5d0\uc11c \ud754\ud788 \uac15\uc870\ub418\ub294 \uac1c\ub150\uc740 \u2018\ub2e8\ubc31\uc9c8 \ud569\uc131\u2019\uc774\ub2e4. \uc6b4\ub3d9\uc73c\ub85c \uadfc\uc721\uc5d0 \uc790\uadf9\uc744 \uc8fc\uba74 \ub2e8\ubc31\uc9c8 \ud569\uc131\uc774 \uc99d\uac00\ud558\uace0, \uc7a5\uae30\uc801\uc73c\ub85c \uadfc\ube44\ub300\uc640 \uadfc\ub825 \ud5a5\uc0c1\uc774 \uc77c\uc5b4\ub09c\ub2e4\ub294 \uc124\uba85\uc774\ub2e4. \uadf8\ub7ec\ub098 \uadfc\uc721 \uc801\uc751\uc744 \uc774\ud574\ud558\ub824\uba74 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4dc\ub294 \uacfc\uc815\ub9cc\ud07c\uc774\ub098 \uc774\ubbf8 \uc190\uc0c1\ub418\uac70\ub098 \uae30\ub2a5\uc744 \uc783\uc740 \ub2e8\ubc31\uc9c8\uc744 \uc5b4\ub5bb\uac8c \ucc3e\uc544\ub0b4\uace0 \uc81c\uac70\ud558\ub294\uac00<\/strong>\ub3c4 \uc911\uc694\ud558\ub2e4.<\/p>\n

\ud2b9\ud788 \uace0\uac15\ub3c4 \uc800\ud56d\uc6b4\ub3d9\ucc98\ub7fc \uadfc\uc721\uc5d0 \ud070 \uae30\uacc4\uc801 \uc7a5\ub825(mechanical tension)<\/strong>\uc774 \ubc1c\uc0dd\ud558\uba74 \uadfc\uc721 \ub0b4\ubd80\uc758 \ud798 \uc804\ub2ec \uad6c\uc870 \uc5ed\uc2dc \uc0c1\ub2f9\ud55c \uc2a4\ud2b8\ub808\uc2a4\ub97c \ubc1b\ub294\ub2e4. \uc774\ub54c \ud575\uc2ec\uc801\uc73c\ub85c \ub4f1\uc7a5\ud558\ub294 \ub2e8\ubc31\uc9c8\uc774 FLNC(Filamin C)<\/strong>\uc774\uace0, \uc190\uc0c1\ub41c FLNC\ub97c \ucc98\ub9ac\ud558\ub294 \ub300\ud45c\uc801\uc778 \uc2dc\uc2a4\ud15c\uc774 CASA(Chaperone-Assisted Selective Autophagy, \uc0e4\ud398\ub860 \ubcf4\uc870 \uc120\ud0dd\uc801 \uc790\uac00\ud3ec\uc2dd)<\/strong>\ub2e4.<\/p>\n

Ulbricht \uc5f0\uad6c\ud300\uc740 \uc0ac\ub78c \uace8\uaca9\uadfc\uc5d0\uc11c CASA\uac00 \uc2e4\uc81c \uc800\ud56d\uc6b4\ub3d9\uc5d0 \ubc18\uc751\ud558\ub294\uc9c0\ub97c \uc5f0\uad6c\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 CASA\ub97c \uadfc\uc721 \uc218\ucd95 \uacfc\uc815\uc5d0\uc11c \uc190\uc0c1\ub41c \ud070 \uc138\ud3ec\uace8\uaca9 \ub2e8\ubc31\uc9c8\uc744 \uc81c\uac70\ud558\ub294 \uc911\uc694\ud55c \ub2e8\ubc31\uc9c8 \ud488\uc9c8\uad00\ub9ac \uae30\uc804\uc73c\ub85c \uc124\uba85\ud55c\ub2e4.<\/p>\n

\uc774 \uacfc\uc815\uc744 \uc774\ud574\ud558\ub824\uba74 \uba3c\uc800 FLNC\ubd80\ud130 \ud558\ub098\uc529 \ud480\uc5b4\ubcfc \ud544\uc694\uac00 \uc788\ub2e4.<\/p>\n

\n

\uadfc\uc721\uc758 \u2018\ud798 \uc804\ub2ec \uad6c\uc870\ubb3c\u2019 FLNC, \uc65c \uc911\uc694\ud55c\uac00<\/h2>\n

\uadfc\uc721\uc744 \ub2e8\uc21c\ud788 \uc561\ud2f4\uacfc \ubbf8\uc624\uc2e0\uc774 \ubbf8\ub044\ub7ec\uc9c0\ub294 \uad6c\uc870\ub85c\ub9cc \uc0dd\uac01\ud558\uae30 \uc27d\uc9c0\ub9cc, \uc2e4\uc81c \uadfc\uc721\uc740 \ubc1c\uc0dd\ud55c \ud798\uc744 \uc548\uc815\uc801\uc73c\ub85c \uc804\ub2ec\ud558\uae30 \uc704\ud55c \ubcf5\uc7a1\ud55c \uad6c\uc870\ubb3c\uc744 \uac00\uc9c0\uace0 \uc788\ub2e4.<\/p>\n

\uadf8 \uac00\uc6b4\ub370 \uc911\uc694\ud55c \ubd80\uc704\uac00 Z-disk, \uc989 Z\uc120<\/strong>\uc774\ub2e4.<\/p>\n

Z-disk\ub294 \uadfc\uc808(sarcomere)\uc758 \uacbd\uacc4\ub97c \ud615\uc131\ud558\uba74\uc11c \uc561\ud2f4 \ud544\ub77c\uba58\ud2b8\ub97c \uace0\uc815\ud558\uace0, \uadfc\uc218\ucd95 \uacfc\uc815\uc5d0\uc11c \ub9cc\ub4e4\uc5b4\uc9c0\ub294 \ud798\uc744 \uad6c\uc870\uc801\uc73c\ub85c \uc9c0\ud0f1\ud558\ub294 \ubd80\uc704\ub2e4. \ub17c\ubb38\uc740 CASA\uac00 \ubc14\ub85c \uc774 Z-disk\uc5d0\uc11c \uc791\ub3d9\ud55c\ub2e4\uace0 \uc124\uba85\ud55c\ub2e4.<\/p>\n

\uadf8\ub9ac\uace0 \uc774 Z-disk\uc5d0 \uc704\uce58\ud558\ub294 \uc911\uc694\ud55c \ub2e8\ubc31\uc9c8 \uac00\uc6b4\ub370 \ud558\ub098\uac00 FLNC, Filamin C<\/strong>\ub2e4.<\/p>\n

FLNC\ub294 \uc561\ud2f4(actin)\uc744 \uc11c\ub85c \uc5f0\uacb0\ud574\uc8fc\ub294 actin-crosslinking protein<\/strong>, \uc989 \uc561\ud2f4 \uac00\uad50 \ub2e8\ubc31\uc9c8\uc774\ub2e4. \ub17c\ubb38\uc5d0 \ub530\ub974\uba74 FLNC\ub294 \uc57d 500 kDa \uaddc\ubaa8\uc758 \ud070 \ub2e8\ubc31\uc9c8 \ubcf5\ud569\uccb4\uc774\uba70, \uae38\ucb49\ud55c rod \ud615\ud0dc\uc758 \uad6c\uc870\uc640 \uc561\ud2f4 \uacb0\ud569 \ubd80\uc704\ub97c \uac00\uc9c0\uace0 \uc788\ub2e4.<\/p>\n

\uc27d\uac8c \ud45c\ud604\ud558\uba74 FLNC\ub294 \uadfc\uc721 \ub0b4\ubd80\uc5d0\uc11c<\/p>\n

\u201c\uc561\ud2f4 \uad6c\uc870\ubb3c\uc744 \uc5f0\uacb0\ud558\uace0, \ud798\uc774 \uac78\ub9b4 \ub54c \uad6c\uc870\uac00 \ubb34\ub108\uc9c0\uc9c0 \uc54a\ub3c4\ub85d \ubc84\ud168\uc8fc\ub294 \uc5f0\uacb0 \ubd80\ud488\u201d<\/strong><\/p>\n

\uac00\uc6b4\ub370 \ud558\ub098\ub77c\uace0 \ubcfc \uc218 \uc788\ub2e4.<\/p>\n

\uadf8\ub7f0\ub370 FLNC\uc5d0\ub294 \uc911\uc694\ud55c \ud2b9\uc9d5\uc774 \uc788\ub2e4.<\/p>\n

\ud798\uc744 \uc804\ub2ec\ud558\ub294 \uad6c\uc870\ubb3c\uc778 \ub9cc\ud07c, \uc6b4\ub3d9 \uc911 \uac15\ud55c \uae30\uacc4\uc801 \uc7a5\ub825\uc774 \ubc1c\uc0dd\ud558\uba74 FLNC \uc790\uccb4\ub3c4 \uadf8 \ud798\uc744 \uace0\uc2a4\ub780\ud788 \ubc1b\ub294\ub2e4.<\/p>\n

\ub17c\ubb38\uc5d0\uc11c\ub294 \uc561\ud2f4 \ub124\ud2b8\uc6cc\ud06c\uc758 \uc218\ucd95\uc5d0 \uc758\ud574 FLNC \ub0b4\ubd80\uc758 \ub2e8\ubc31\uc9c8 \ub3c4\uba54\uc778\uc774 mechanical unfolding<\/strong>, \uc989 \uae30\uacc4\uc801\uc778 \ud798\uc5d0 \uc758\ud574 \ud3bc\uccd0\uc9c8 \uc218 \uc788\ub2e4\uace0 \uc124\uba85\ud55c\ub2e4.<\/p>\n

\uc5ec\uae30\uc11c \u2018unfolding\u2019\uc740 \uc911\uc694\ud55c \uac1c\ub150\uc774\ub2e4.<\/p>\n

\ub2e8\ubc31\uc9c8\uc740 \ub2e8\uc21c\ud55c \uc2e4\ucc98\ub7fc \uc874\uc7ac\ud558\uc9c0 \uc54a\ub294\ub2e4. \ud2b9\uc815\ud55c 3\ucc28\uc6d0 \uad6c\uc870\ub85c \uc811\ud600 \uc788\uc5b4\uc57c \uc815\uc0c1\uc801\uc778 \uae30\ub2a5\uc744 \ud55c\ub2e4. \uadf8\ub7f0\ub370 \uc9c0\ub098\uce58\uac8c \uac15\ud55c \ud798\uc774 \uac00\ud574\uc9c0\uba74 \uc77c\ubd80 \uad6c\uc870\uac00 \ud3bc\uccd0\uc9c0\uace0 \uc815\uc0c1\uc801\uc778 \ud615\ud0dc\ub97c \uc783\uc744 \uc218 \uc788\ub2e4.<\/p>\n

\uc989,<\/p>\n

\uae30\uacc4\uc801 \uc7a5\ub825 \uc99d\uac00 \u2192 FLNC \uad6c\uc870 \ubcc0\ud654 \ub610\ub294 \uc190\uc0c1<\/strong><\/p>\n

\uc774 \uc77c\uc5b4\ub09c\ub2e4.<\/p>\n

\ubb38\uc81c\ub294 \uc774\ub807\uac8c \ubcc0\ud615\ub41c FLNC\ub97c \uadf8\ub300\ub85c \ub194\ub458 \uacbd\uc6b0\ub2e4.<\/p>\n

\ud798\uc744 \uc804\ub2ec\ud574\uc57c \ud560 \uad6c\uc870 \ub2e8\ubc31\uc9c8\uc774 \uc815\uc0c1\uc801\uc778 \ud615\ud0dc\ub97c \uc783\uc740 \ucc44 \uacc4\uc18d \ub0a8\uc544 \uc788\ub2e4\uba74 Z-disk\uc640 \uc138\ud3ec\uace8\uaca9\uc758 \uc548\uc815\uc131\uc774 \ub5a8\uc5b4\uc9c8 \uc218 \uc788\ub2e4.<\/p>\n

\ub530\ub77c\uc11c \uadfc\uc721\uc5d0\ub294 \ub9dd\uac00\uc9c4 FLNC\ub97c \ucc3e\uc544\ub0b4\ub294 \u2018\uac80\uc0ac \uc2dc\uc2a4\ud15c\u2019\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n

\uadf8 \uc5ed\ud560\uc744 \ub2f4\ub2f9\ud558\ub294 \uac83\uc774 CASA\ub2e4.<\/p>\n

\n

BAG3\uac00 \ub4f1\uc7a5\ud55c\ub2e4\u2026 CASA\ub294 \ud558\ub098\uc758 \ub2e8\ubc31\uc9c8\uc774 \uc544\ub2c8\ub2e4<\/h2>\n

CASA\ub97c \uc774\ud574\ud560 \ub54c \uac00\uc7a5 \uba3c\uc800 \uc54c\uc544\uc57c \ud560 \uc810\uc740 CASA\ub77c\ub294 \uc774\ub984\uc758 \ub2e8\uc77c \ub2e8\ubc31\uc9c8\uc774 \uc874\uc7ac\ud558\ub294 \uac83\uc774 \uc544\ub2c8\ub77c\ub294 \uac83<\/strong>\uc774\ub2e4.<\/p>\n

CASA\ub294 \uc5ec\ub7ec \ub2e8\ubc31\uc9c8\uc774 \ud611\ub825\ud574 \uc190\uc0c1\ub41c \ub2e8\ubc31\uc9c8\uc744 \ubc1c\uacac\ud558\uace0 \uc81c\uac70\ud558\ub294 \uacbd\ub85c(pathway)<\/strong>\ub2e4.<\/p>\n

\uadf8 \uc911\uc2ec\uc5d0 \uc788\ub294 \uac83\uc774<\/p>\n

BAG3
\nHSPB8
\nHSPA8\/HSC70<\/strong><\/p>\n

\ub4f1\uc758 \ub2e8\ubc31\uc9c8\uc774\ub2e4.<\/p>\n

\ub17c\ubb38\uc5d0\uc11c\ub294 FLNC\uac00 \uae30\uacc4\uc801 \uc7a5\ub825\uc5d0 \uc758\ud574 \ud3bc\uccd0\uc9c0\uba74 CASA chaperone complex\uc5d0 \uc758\ud574 \uc778\uc2dd\ub41c\ub2e4\uace0 \uc124\uba85\ud55c\ub2e4. \uc774 \ubcf5\ud569\uccb4\uc5d0\ub294 \ubd84\uc790 \uc0e4\ud398\ub860\uc778 HSPA8\/HSC70\uacfc HSPB8\/HSP22<\/strong>, \uadf8\ub9ac\uace0 \uc774\ub97c \uc5f0\uacb0\ud558\ub294 BAG3<\/strong>\uac00 \ud3ec\ud568\ub41c\ub2e4. \ud2b9\ud788 BAG3\ub294 CASA\ub97c \uc2dc\uc791\ud558\ub294 \ub370 \ud544\uc218\uc801\uc778 cochaperone\uc73c\ub85c \uc81c\uc2dc\ub41c\ub2e4.<\/p>\n

\uc5ec\uae30\uc11c \uba3c\uc800 \uc0e4\ud398\ub860(chaperone)<\/strong>\uc774 \ubb34\uc5c7\uc778\uc9c0 \uc54c\uc544\uc57c \ud55c\ub2e4.<\/p>\n

\uc0e4\ud398\ub860\uc740 \uc27d\uac8c \ub9d0\ud558\uba74 \ub2e8\ubc31\uc9c8\uc758 \uc0c1\ud0dc\ub97c \uac10\uc2dc\ud558\uace0 \uad00\ub9ac\ud558\ub294 \ub2e8\ubc31\uc9c8<\/strong>\uc774\ub2e4.<\/p>\n

\ub2e8\ubc31\uc9c8\uc774 \uc815\uc0c1\uc801\uc73c\ub85c \uc811\ud788\ub3c4\ub85d \ub3d5\uae30\ub3c4 \ud558\uace0, \uc5f4\u00b7\uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub098 \uae30\uacc4\uc801 \uc2a4\ud2b8\ub808\uc2a4\ub85c \uc778\ud574 \ube44\uc815\uc0c1\uc801\uc73c\ub85c \uc811\ud78c \ub2e8\ubc31\uc9c8\uc744 \uc778\uc2dd\ud558\uae30\ub3c4 \ud55c\ub2e4.<\/p>\n

\uadf8\ub798\uc11c HSP \uacc4\uc5f4 \ub2e8\ubc31\uc9c8\uc744 \ud754\ud788 \u2018\uc2a4\ud2b8\ub808\uc2a4 \ub2e8\ubc31\uc9c8\u2019\uc774\ub77c\uace0 \ubd80\ub974\uae30\ub3c4 \ud55c\ub2e4.<\/p>\n

\uadf8\uc911 HSPB8<\/strong>\uc740 \uc791\uc740 heat shock protein \uacc4\uc5f4\uc5d0 \uc18d\ud558\ub294 \uc0e4\ud398\ub860\uc774\uace0, HSPA8\/HSC70<\/strong> \uc5ed\uc2dc \ub2e8\ubc31\uc9c8 \ud488\uc9c8\uad00\ub9ac\uc640 \uad00\ub828\ub41c \ub300\ud45c\uc801\uc778 \uc0e4\ud398\ub860\uc774\ub2e4.<\/p>\n

\ud558\uc9c0\ub9cc \uc774\ub4e4\uc774 \uac01\uac01 \ub3c5\ub9bd\uc801\uc73c\ub85c \ud589\ub3d9\ud558\ub294 \uac83\uc740 \uc544\ub2c8\ub2e4.<\/p>\n

\uc774\ub4e4\uc744 CASA\ub77c\ub294 \ud558\ub098\uc758 \ud488\uc9c8\uad00\ub9ac \uc2dc\uc2a4\ud15c\uc73c\ub85c \uc870\uc9c1\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \uac83\uc774 BAG3<\/strong>\ub2e4.<\/p>\n

BAG3\uc758 \uc815\ud655\ud55c \uc774\ub984\uc740 BCL2-associated athanogene 3<\/strong>\uc774\ub2e4.<\/p>\n

\ub17c\ubb38\uc5d0\uc11c\ub294 BAG3\ub97c cochaperone<\/strong>, \uc989 \uc0e4\ud398\ub860\uc744 \ubcf4\uc870\ud558\uace0 \uc5f0\uacb0\ud558\ub294 \ub2e8\ubc31\uc9c8\ub85c \uc124\uba85\ud55c\ub2e4. BAG3 \uc790\uccb4\uac00 FLNC\ub97c \uc9c1\uc811 \uc798\ub77c\ubc84\ub9ac\ub294 \ud6a8\uc18c\ub77c\uae30\ubcf4\ub2e4\ub294, \uc190\uc0c1\ub41c \ub2e8\ubc31\uc9c8\uc744 \ucc98\ub9ac\ud558\uae30 \uc704\ud574 \uc5ec\ub7ec \ub2e8\ubc31\uc9c8\uc744 \ud55c \uc2dc\uc2a4\ud15c \uc548\uc73c\ub85c \ubaa8\uc73c\uace0 \ub2e4\uc74c \ub2e8\uacc4\ub85c \ub118\uae30\ub294 \uc870\uc815\uc790\u00b7\uc5b4\ub311\ud130 \uc5ed\ud560<\/strong>\uc5d0 \uac00\uae5d\ub2e4.<\/p>\n

\uc774\ub97c \ube44\uc720\ud558\uba74,<\/p>\n

FLNC\uac00 \u2018\uc190\uc0c1\ub41c \ubd80\ud488\u2019\uc774\ub77c\uba74
\nHSPB8\uacfc HSPA8\uc740 \u2018\ubd80\ud488\uc758 \uc774\uc0c1 \uc5ec\ubd80\ub97c \uac80\uc0ac\ud558\ub294 \ud488\uc9c8\uad00\ub9ac\ud300\u2019\uc774\uace0
\nBAG3\ub294 \u2018\uc774\uc0c1 \ubd80\ud488\uc744 \ud3d0\uae30 \uc2dc\uc2a4\ud15c\uc73c\ub85c \ub118\uae30\ub3c4\ub85d \uc791\uc5c5\uc744 \uc5f0\uacb0\ud558\ub294 \uad00\ub9ac\uc790\u2019\uc5d0 \uac00\uae5d\ub2e4.<\/p>\n

\n

\uc190\uc0c1\ub41c FLNC\uc5d0 \u2018\ud3d0\uae30 \ud45c\uc2dc\u2019\ub97c \ubd99\uc778\ub2e4\u2026 ubiquitination<\/h2>\n

CASA\uac00 FLNC\ub97c \uc190\uc0c1\ub41c \ub2e8\ubc31\uc9c8\uc774\ub77c\uace0 \ud310\ub2e8\ud588\ub2e4\uace0 \ud574\uc11c \ubc14\ub85c \ub9ac\uc18c\uc880\uc73c\ub85c \ub4e4\uc5b4\uac00\ub294 \uac83\uc740 \uc544\ub2c8\ub2e4.<\/p>\n

\uba3c\uc800 \uc911\uc694\ud55c \uacfc\uc815\uc774 \ud558\ub098 \ub354 \ud544\uc694\ud558\ub2e4.<\/p>\n

\ubc14\ub85c ubiquitination, \uc720\ube44\ud034\ud2f4\ud654<\/strong>\ub2e4.<\/p>\n

\uc77c\ubc18\uc801\uc778 \uc138\ud3ec\uc0dd\ubb3c\ud559\uc5d0\uc11c ubiquitin\uc740 \uc791\uc740 \ub2e8\ubc31\uc9c8 \ud45c\uc9c0\uc790\ub85c \uc774\ud574\ud560 \uc218 \uc788\ub2e4. \ud2b9\uc815 \ub2e8\ubc31\uc9c8\uc5d0 ubiquitin\uc774 \ubd99\uc73c\uba74 \uadf8 \ub2e8\ubc31\uc9c8\uc758 \uc704\uce58, \uae30\ub2a5 \ub610\ub294 \ubd84\ud574 \uc5ec\ubd80\ub97c \uc138\ud3ec\uac00 \uacb0\uc815\ud560 \uc218 \uc788\ub2e4.<\/p>\n

CASA\uc5d0\uc11c\ub294 BAG3\uac00 STUB1\/CHIP<\/strong>\uc774\ub77c\ub294 ubiquitin ligase\uc640 \ud611\ub825\ud558\uace0, \uc5ec\uae30\uc5d0 UBE2D<\/strong>\ub77c\ub294 ubiquitin-conjugating enzyme\uc774 \ud568\uaed8 \uc791\ub3d9\ud574 CASA \ubcf5\ud569\uccb4\uac00 \ubd99\uc7a1\uace0 \uc788\ub294 FLNC\uc5d0 ubiquitin\uc744 \ubd99\uc778\ub2e4.<\/p>\n

\uc5ec\uae30\uc11c CHIP\uc740 \uc77c\uc885\uc758 E3 ubiquitin ligase<\/strong>\ub2e4.<\/p>\n

\uac04\ub2e8\ud788 \ub9d0\ud558\uba74<\/p>\n

\u201c\uc774 \ub2e8\ubc31\uc9c8\uc5d0 ubiquitin\uc744 \ubd99\uc5ec\ub77c\u201d<\/strong><\/p>\n

\ub77c\ub294 \uc791\uc5c5\uc744 \uc2e4\uc81c \ub300\uc0c1 \ub2e8\ubc31\uc9c8\uacfc \uc5f0\uacb0\ud558\ub294 \uc5ed\ud560\uc744 \ud55c\ub2e4.<\/p>\n

\ub530\ub77c\uc11c \uacfc\uc815\uc740 \uc870\uae08 \ub354 \uc815\ud655\ud558\uac8c \uc4f0\uba74 \ub2e4\uc74c\uacfc \uac19\ub2e4.<\/p>\n

\uae30\uacc4\uc801\uc73c\ub85c \uc190\uc0c1\ub41c FLNC
\n\u2192 HSPB8\/HSPA8\u2013BAG3 CASA complex\uac00 \uc778\uc2dd
\n\u2192 CHIP\/STUB1\u00b7UBE2D \uc791\ub3d9
\n\u2192 FLNC\uc5d0 ubiquitin \ud45c\uc9c0<\/strong><\/p>\n

\uac00 \ub41c\ub2e4.<\/p>\n

\uc774 ubiquitin\uc740 \ub2e8\uc21c\ud55c \u2018\uc4f0\ub808\uae30 \uc2a4\ud2f0\ucee4\u2019\ub77c\uace0\ub9cc \ubcf4\uba74 \uc870\uae08 \ubd80\uc815\ud655\ud558\uc9c0\ub9cc, CASA\uc758 \ub9e5\ub77d\uc5d0\uc11c\ub294 \uc190\uc0c1\ub41c FLNC\ub97c \uc790\uac00\ud3ec\uc2dd \uc2dc\uc2a4\ud15c\uc73c\ub85c \ubcf4\ub0b4\uae30 \uc704\ud55c \uc911\uc694\ud55c \uc2e0\ud638<\/strong>\uac00 \ub41c\ub2e4.<\/p>\n

\n

SQSTM1\/p62\ub294 \u2018\ud0dd\ubc30 \uae30\uc0ac\u2019 \uac19\uc740 \uc5ed\ud560<\/h2>\n

\uc774\uc81c ubiquitin\uc774 \ubd99\uc740 FLNC\uac00 \ub9cc\ub4e4\uc5b4\uc84c\ub2e4.<\/p>\n

\ub2e4\uc74c \ub4f1\uc7a5\uc778\ubb3c\uc774 SQSTM1<\/strong>, \ud754\ud788 p62<\/strong>\ub77c\uace0 \ubd80\ub974\ub294 \ub2e8\ubc31\uc9c8\uc774\ub2e4.<\/p>\n

\ub17c\ubb38\uc5d0\uc11c\ub294 FLNC\uc5d0 ubiquitin\uc774 \ubd99\ub294 \uac83\uc774 autophagic ubiquitin receptor\uc778 SQSTM1\uc744 \ubaa8\uc9d1\ud558\ub294 \uc2e0\ud638<\/strong>\uac00 \ub41c\ub2e4\uace0 \uc124\uba85\ud55c\ub2e4.<\/p>\n

SQSTM1\uc740 \uc0c1\ub2f9\ud788 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4.<\/p>\n

\uc190\uc0c1\ub41c \ub2e8\ubc31\uc9c8\uc5d0 ubiquitin\uc774 \ubd99\uc5b4 \uc788\ub2e4\uace0 \ud574\uc11c \uadf8\uac83\uc774 \uc790\ub3d9\uc73c\ub85c autophagosome \uc18d\uc73c\ub85c \ub4e4\uc5b4\uac00\ub294 \uac83\uc740 \uc544\ub2c8\ub2e4.<\/p>\n

\ub204\uad70\uac00<\/p>\n

\u201c\uc5ec\uae30 \uc81c\uac70\ud574\uc57c \ud558\ub294 \ub2e8\ubc31\uc9c8\uc774 \uc788\ub2e4\u201d<\/strong><\/p>\n

\uace0 \uc790\uac00\ud3ec\uc2dd \uc7a5\uce58\uc5d0 \uc5f0\uacb0\ud574\uc918\uc57c \ud55c\ub2e4.<\/p>\n

\uadf8 \uc5f0\uacb0 \uc5ed\ud560\uc744 \ud558\ub294 \uac83\uc774 SQSTM1\/p62 \uac19\uc740 autophagy receptor<\/strong>, \uc989 \uc790\uac00\ud3ec\uc2dd \uc218\uc6a9\uccb4\ub2e4.<\/p>\n

\ub530\ub77c\uc11c \uc774\ud574\ud558\uae30 \uc27d\uac8c \ud45c\ud604\ud558\uba74<\/p>\n

ubiquitin = \uc81c\uac70 \ub300\uc0c1\uc774\ub77c\ub294 \ud45c\uc9c0<\/strong><\/p>\n

\ub77c\uba74,<\/p>\n

SQSTM1\/p62 = \uadf8 \ud45c\uc9c0\ub97c \uc77d\uace0 \uc790\uac00\ud3ec\uc2dd \uc7a5\uce58\ub85c \uc5f0\uacb0\ud558\ub294 \uc6b4\ubc18\u00b7\uc911\uac1c \ub2e8\ubc31\uc9c8<\/strong><\/p>\n

\uc774\ub77c\uace0 \ubcfc \uc218 \uc788\ub2e4.<\/p>\n

\n

SYNPO2\ub294 \uc790\uac00\ud3ec\uc2dd \ub9c9 \ud615\uc131\uacfc CASA\ub97c \uc5f0\uacb0\ud55c\ub2e4<\/h2>\n

CASA \uacfc\uc815\uc5d0\ub294 SYNPO2(synaptopodin-2)<\/strong>\ub3c4 \ub4f1\uc7a5\ud55c\ub2e4.<\/p>\n

\ub17c\ubb38\uc5d0 \ub530\ub974\uba74 BAG3\ub294 SYNPO2\uc640 \uc0c1\ud638\uc791\uc6a9\ud558\uace0, SYNPO2\ub294 \ub2e4\uc2dc VPS \ubc0f SNARE \ub2e8\ubc31\uc9c8\uc744 \ud3ec\ud568\ud558\ub294 \ub9c9 \uc735\ud569 \uc7a5\uce58\uc640 \uc5f0\uacb0\ub41c\ub2e4. \uc774 \uacfc\uc815\uc740 autophagosome \ud615\uc131\uacfc \uad00\ub828\ub41c\ub2e4.<\/p>\n

\uc989 CASA\ub294 \ub2e8\uc21c\ud788<\/p>\n

\u201c\uc190\uc0c1 \ub2e8\ubc31\uc9c8\uc744 \ucc3e\uc558\ub2e4.\u201d<\/p>\n

\uc5d0\uc11c \ub05d\ub098\ub294 \uac8c \uc544\ub2c8\ub2e4.<\/p>\n

\uadf8 \uc190\uc0c1 \ub2e8\ubc31\uc9c8\uc744 \uc2e4\uc81c \uc790\uac00\ud3ec\uc2dd \uad6c\uc870 \uc18d\uc5d0 \ub123\uae30 \uc704\ud574 \ub9c9\uc744 \ub9cc\ub4e4\uace0 \uc774\ub3d9\uc2dc\ud0a4\uace0 \uc735\ud569\ud558\ub294 \uc2dc\uc2a4\ud15c<\/strong>\uae4c\uc9c0 \uc5f0\uacb0\ud574\uc57c \ud55c\ub2e4.<\/p>\n

\n

autophagosome\uc740 \uc4f0\ub808\uae30\ud1b5\uc774 \uc544\ub2c8\ub77c \u2018\uc6b4\ubc18\uc6a9 \uaca9\ub9ac\ub9c9\u2019<\/h2>\n

\ub2e4\uc74c \ub2e8\uacc4\uac00 autophagosome, \uc624\ud1a0\ud30c\uace0\uc880<\/strong>\uc774\ub2e4.<\/p>\n

autophagosome\uc740 \uc81c\uac70\ud574\uc57c \ud560 \uc138\ud3ec \ub0b4 \ubb3c\uc9c8\uc744 \ub9c9\uc73c\ub85c \ub458\ub7ec\uc2f8\ub294 \uad6c\uc870\ub2e4.<\/p>\n

\uc790\uac00\ud3ec\uc2dd(autophagy)\uc774\ub77c\ub294 \ub2e8\uc5b4 \ub54c\ubb38\uc5d0 \uc885\uc885<\/p>\n

\u201c\uc138\ud3ec\uac00 \uc790\uae30 \uc790\uc2e0\uc744 \uba39\uc5b4\ubc84\ub9ac\ub294 \uac83\u201d<\/p>\n

\uc774\ub77c\uace0 \ub2e8\uc21c\ud558\uac8c \uc774\ud574\ud558\uc9c0\ub9cc, CASA\uc5d0\uc11c\ub294 \uc870\uae08 \ub2e4\ub978 \uc2dc\uac01\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n

\uc5ec\uae30\uc11c\ub294 \ubaa8\ub4e0 \ub2e8\ubc31\uc9c8\uc744 \ubb34\ucc28\ubcc4\uc801\uc73c\ub85c \ubd84\ud574\ud558\ub294 \uac83\uc774 \uc544\ub2c8\ub77c,<\/p>\n

\uae30\uacc4\uc801 \uc190\uc0c1\uc744 \uc785\uc740 \ud2b9\uc815 \uad6c\uc870 \ub2e8\ubc31\uc9c8\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \uace8\ub77c \uc81c\uac70\ud55c\ub2e4.<\/strong><\/p>\n

\uadf8\ub798\uc11c \uc774\ub984\uc5d0\ub3c4 Selective Autophagy<\/strong>, \uc989 \u2018\uc120\ud0dd\uc801 \uc790\uac00\ud3ec\uc2dd\u2019\uc774\ub77c\ub294 \ud45c\ud604\uc774 \ub4e4\uc5b4\uac04\ub2e4.<\/p>\n

\uc2e4\uc81c\ub85c \ucd5c\ub300 eccentric \uc800\ud56d\uc6b4\ub3d9 \uc774\ud6c4 \uc5f0\uad6c\uc9c4\uc740 autophagosome membrane marker\uc778 LC3\uc640 FLNC, BAG3\uc758 \uacf5\uc704\uce58\uac00 \uc99d\uac00\ud558\ub294 \uac83\uc744 \uad00\ucc30\ud588\ub2e4. FLNC-LC3 \uacf5\uc704\uce58\ub294 \uc57d 1.55\ubc30, BAG3-LC3\ub294 \uc57d 1.54\ubc30 \uc99d\uac00\ud588\ub2e4. \uc774\ub294 FLNC\uc640 BAG3\uac00 \uc2e4\uc81c\ub85c autophagic structure\ub85c \uc774\ub3d9\ud55c\ub2e4\ub294 \uadfc\uac70\ub85c \ud574\uc11d\ub410\ub2e4.<\/p>\n

\n

\ub9c8\uc9c0\ub9c9 \ubaa9\uc801\uc9c0\ub294 lysosome\u2026 \uc190\uc0c1\ub41c FLNC\ub97c \uc2e4\uc81c\ub85c \ubd84\ud574\ud55c\ub2e4<\/h2>\n

autophagosome\uc774 \ub9cc\ub4e4\uc5b4\uc84c\ub2e4\uace0 \uc791\uc5c5\uc774 \ub05d\ub09c \uac83\uc740 \uc544\ub2c8\ub2e4.<\/p>\n

\ucd5c\uc885 \ubaa9\uc801\uc9c0\ub294 lysosome, \ub9ac\uc18c\uc880<\/strong>\uc774\ub2e4.<\/p>\n

\uc77c\ubc18 \uc138\ud3ec\uc0dd\ubb3c\ud559\uc801\uc73c\ub85c \ub9ac\uc18c\uc880\uc740 \ub2e4\uc591\ud55c \ubd84\ud574 \ud6a8\uc18c\ub97c \uac00\uc9c0\uace0 \uc788\ub294 \uc138\ud3ec \ub0b4 \ubd84\ud574 \uae30\uad00\uc774\ub2e4.<\/p>\n

\ub17c\ubb38\uc5d0\uc11c\ub294 autophagosome\uc774 \uacb0\uad6d lysosome\uacfc \uc735\ud569\ud558\uace0, \uadf8 \uc548\uc5d0\uc11c \uc190\uc0c1\ub41c FLNC\uac00 \ubd84\ud574\ub41c\ub2e4\uace0 \uc124\uba85\ud55c\ub2e4. \uadf8\ub9ac\uace0 \uc774\ub7ec\ud55c FLNC \uc81c\uac70 \uacfc\uc815\uc774 \ub05d\ub09c \ub4a4 \uc0c8\ub86d\uac8c \ub9cc\ub4e4\uc5b4\uc9c4 \uc815\uc0c1 FLNC\uac00 Z-disk\uc5d0 \ub4e4\uc5b4\uac08 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \uc81c\uc2dc\ud55c\ub2e4.<\/p>\n

\uc774 \ubd80\ubd84\uc774 CASA\ub97c \uc774\ud574\ud558\ub294 \ub370 \uac00\uc7a5 \uc911\uc694\ud558\ub2e4.<\/p>\n

\uc6b4\ub3d9\uc5d0 \uc758\ud574 \ub2e8\ubc31\uc9c8\uc774 \uc190\uc0c1\ub410\ub2e4\ub294 \uc0ac\uc2e4 \uc790\uccb4\uac00 \uc801\uc751\uc740 \uc544\ub2c8\ub2e4.<\/p>\n

\uc190\uc0c1\ub41c \uad6c\uc870\ubb3c\uc744 \uc81c\uac70\ud558\uace0 \uc0c8\ub85c\uc6b4 \uad6c\uc870\ubb3c\ub85c \uad50\uccb4\ud574\uc57c \uc801\uc751 \uacfc\uc815\uc774 \uc644\uc131\ub420 \uc218 \uc788\ub2e4.<\/strong><\/p>\n

\uc989 \uadfc\uc721\uc5d0\uc11c\ub294<\/p>\n

\ud30c\uad34 \u2192 \uc81c\uac70 \u2192 \uc7ac\ud569\uc131<\/strong><\/p>\n

\uc774 \ud558\ub098\uc758 \uc5f0\uc18d\ub41c \uacfc\uc815\uc774\ub2e4.<\/p>\n

\n

\u201c\uadfc\uc721 \uc131\uc7a5 = \ud569\uc131\u201d\ub9cc\uc73c\ub85c\ub294 \uc124\uba85\uc774 \ubd80\uc871\ud558\ub2e4<\/h1>\n

\ub530\ub77c\uc11c \uc800\ud56d\uc6b4\ub3d9\uc744 \ub2e4\uc74c\ucc98\ub7fc \ub2e8\uc21c\ud558\uac8c \uc124\uba85\ud558\ub294 \uac83\uc740 \ubd80\uc871\ud558\ub2e4.<\/p>\n

\uc800\ud56d\uc6b4\ub3d9 \u2192 mTOR \ud65c\uc131 \u2192 \ub2e8\ubc31\uc9c8 \ud569\uc131 \u2192 \uadfc\uc721 \uc131\uc7a5<\/strong><\/p>\n

\uc2e4\uc81c \uadfc\uc721\uc5d0\uc11c\ub294 \ub3d9\uc2dc\uc5d0 \ud6e8\uc52c \ubcf5\uc7a1\ud55c \ud488\uc9c8\uad00\ub9ac \uacfc\uc815\uc774 \uc9c4\ud589\ub41c\ub2e4.<\/p>\n

\uc774\ubc88 \ub17c\ubb38\uc758 CASA \uac1c\ub150\uc744 \uc911\uc2ec\uc73c\ub85c \uc815\ub9ac\ud558\uba74 \ub2e4\uc74c\uacfc \uac19\ub2e4.<\/p>\n

\u2460 Mechanical tension<\/strong>
\n\uadfc\uc218\ucd95\uacfc \uc800\ud56d\uc6b4\ub3d9\uc73c\ub85c Z-disk\uc640 \uc138\ud3ec\uace8\uaca9\uc5d0 \ud798\uc774 \uc804\ub2ec\ub41c\ub2e4.<\/p>\n

\u2461 FLNC unfolding\/damage<\/strong>
\n\uc561\ud2f4\uc744 \uc5f0\uacb0\ud558\uace0 \ud798\uc744 \uc804\ub2ec\ud558\ub294 FLNC\uac00 \uacfc\ub3c4\ud55c \uc7a5\ub825\uc5d0 \uc758\ud574 \ud3bc\uccd0\uc9c0\uac70\ub098 \uc190\uc0c1\ub41c\ub2e4.<\/p>\n

\u2462 HSPB8\u00b7HSPA8 + BAG3<\/strong>
\nCASA chaperone complex\uac00 \ube44\uc815\uc0c1\uc801\uc778 FLNC\ub97c \uc778\uc2dd\ud55c\ub2e4.<\/p>\n

\u2463 STUB1\/CHIP + UBE2D \u2192 ubiquitination<\/strong>
\n\uc190\uc0c1\ub41c FLNC\uc5d0 ubiquitin \ud45c\uc9c0\uac00 \ubd99\ub294\ub2e4.<\/p>\n

\u2464 SQSTM1\/p62<\/strong>
\nubiquitin\uc774 \ubd99\uc740 FLNC\ub97c \uc790\uac00\ud3ec\uc2dd \uc2dc\uc2a4\ud15c\uc5d0 \uc5f0\uacb0\ud55c\ub2e4.<\/p>\n

\u2465 SYNPO2\uc640 \ub9c9 \uc735\ud569 machinery<\/strong>
\nautophagosome \ud615\uc131\uc744 \ub3d5\ub294\ub2e4.<\/p>\n

\u2466 autophagosome<\/strong>
\n\uc190\uc0c1\ub41c FLNC\ub97c \ub9c9\uc73c\ub85c \ub458\ub7ec\uc2f8 \uaca9\ub9ac\ud55c\ub2e4.<\/p>\n

\u2467 lysosome<\/strong>
\nautophagosome\uacfc \uc735\ud569\ud574 FLNC\ub97c \ubd84\ud574\ud55c\ub2e4.<\/p>\n

\u2468 \uc0c8\ub85c\uc6b4 FLNC \ud569\uc131\u00b7\uc0bd\uc785<\/strong>
\n\uc190\uc0c1\ub41c \uad6c\uc870 \ub2e8\ubc31\uc9c8\uc744 \uc81c\uac70\ud55c \uc790\ub9ac\uc5d0 \uc0c8\ub86d\uac8c \ub9cc\ub4e4\uc5b4\uc9c4 \uc815\uc0c1 FLNC\uac00 Z-disk \uad6c\uc870\uc5d0 \ub4e4\uc5b4\uac04\ub2e4.<\/p>\n

\uacb0\uad6d \ucc98\uc74c \uc81c\uc2dc\ud588\ub358<\/p>\n

\uae30\uacc4\uc801 \uc7a5\ub825 \u2192 FLNC \uc190\uc0c1 \u2192 BAG3\/HSPB8 \u2192 ubiquitination \u2192 SQSTM1 \u2192 autophagosome \u2192 lysosome \u2192 \uc0c8\ub85c\uc6b4 FLNC<\/strong><\/p>\n

\ub77c\ub294 \ud55c \uc904\uc740 \ub2e8\uc21c\ud55c \u2018\ubd84\ud574 \uacbd\ub85c\u2019\uac00 \uc544\ub2c8\ub2e4.<\/p>\n

\uc774\uac83\uc740 \uadfc\uc721\uc774 \uae30\uacc4\uc801 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uac10\uc9c0\ud558\uace0, \uc190\uc0c1\ub41c \ud798 \uc804\ub2ec \uad6c\uc870\ubb3c\uc744 \uace8\ub77c\ub0b4\uace0, \uc81c\uac70\ud558\uace0, \uc0c8 \uad6c\uc870\ubb3c\ub85c \ub2e4\uc2dc \uc870\ub9bd\ud558\ub294 \ub2e8\ubc31\uc9c8 \ud488\uc9c8\uad00\ub9ac \uacfc\uc815<\/strong>\uc774\ub2e4.<\/p>\n

\ub17c\ubb38 \uc5f0\uad6c\uc9c4\ub3c4 CASA\uac00 \ub2e8\uc21c\ud55c \uc601\uc591 \uacf5\uae09 \ubaa9\uc801\uc758 \uc790\uac00\ud3ec\uc2dd\ubcf4\ub2e4\ub294 protein quality control<\/strong>, \uc989 \ub2e8\ubc31\uc9c8 \ud488\uc9c8\uad00\ub9ac\uc5d0\uc11c \ud575\uc2ec\uc801\uc73c\ub85c \uc791\ub3d9\ud558\uba70, BAG3\uc640 SYNPO2 \uac19\uc740 CASA \uc694\uc18c\uac00 \uae30\uacc4\uc801 \uc2a4\ud2b8\ub808\uc2a4\ub97c \ud06c\uac8c \ubc1b\ub294 Z-disk\uc5d0 \uc704\uce58\ud55c\ub2e4\uace0 \uc124\uba85\ud55c\ub2e4. \ud2b9\ud788 FLNC\ub294 \uc7a5\ub825\uc744 \ubc1b\uc73c\uba74 \uad6c\uc870\uac00 \ud3bc\uccd0\uc9c0\uace0 CASA\uc5d0 \uc758\ud574 \uc778\uc2dd\ub418\ub294 \ub300\ud45c\uc801\uc778 \ud45c\uc801 \ub2e8\ubc31\uc9c8\uc774\ub2e4.<\/p>\n

\uc774 \uad00\uc810\uc5d0\uc11c \ubcf4\uba74 \uc800\ud56d\uc6b4\ub3d9\uc740 \uadfc\uc721\uc5d0\uac8c \ub2e8\uc21c\ud788 \u201c\ub2e8\ubc31\uc9c8\uc744 \ub354 \ub9cc\ub4e4\uc5b4\ub77c\u201d<\/strong>\ub77c\ub294 \uc2e0\ud638\ub9cc \uc8fc\ub294 \uac83\uc774 \uc544\ub2c8\ub2e4.<\/p>\n

\uc624\ud788\ub824<\/p>\n

\u201c\uc9c0\uae08\ubcf4\ub2e4 \ub354 \ud070 \ud798\uc744 \uacac\ub51c \uc218 \uc788\ub3c4\ub85d \uae30\uc874 \uad6c\uc870\ub97c \uac80\uc0ac\ud558\uace0, \ub9dd\uac00\uc9c4 \ubd80\ud488\uc740 \ubc84\ub9ac\uace0, \ud544\uc694\ud55c \ubd80\ud488\uc740 \uc0c8\uac83\uc73c\ub85c \uad50\uccb4\ud558\ub77c.\u201d<\/strong><\/p>\n

\ub77c\ub294 \uc2e0\ud638\uc5d0 \ub354 \uac00\uae5d\ub2e4.<\/p>\n

\uadf8\ub9ac\uace0 \uadf8 \uacfc\uc815\uc5d0\uc11c FLNC\ub294 \uae30\uacc4\uc801 \uc7a5\ub825\uc744 \uc2e4\uc81c\ub85c \ubc1b\uc544\ub4e4\uc774\ub294 \uad6c\uc870 \ub2e8\ubc31\uc9c8 \uc911 \ud558\ub098\uc774\uba70, BAG3\uc640 HSPB8\uc744 \uc911\uc2ec\uc73c\ub85c \ud55c CASA\ub294 \uadf8 \uad6c\uc870\ubb3c\uc758 \uc0c1\ud0dc\ub97c \uad00\ub9ac\ud558\ub294 \uadfc\uc721 \ub0b4\ubd80\uc758 \ud488\uc9c8\uad00\ub9ac \uc2dc\uc2a4\ud15c<\/strong>\uc73c\ub85c \ubcfc \uc218 \uc788\ub2e4.<\/p>\n

\uacb0\uad6d \uadfc\uc721 \uc801\uc751\uc740 \ub2e8\uc21c\ud55c \u2018\ud569\uc131\uc758 \uc99d\uac00\u2019\uac00 \uc544\ub2c8\ub77c \ud569\uc131, \ubd84\ud574, \uc120\ubcc4, \uad50\uccb4\uac00 \ub3d9\uc2dc\uc5d0 \uc870\uc728\ub418\ub294 proteostasis<\/strong>, \uc989 \ub2e8\ubc31\uc9c8 \ud56d\uc0c1\uc131\uc758 \uacb0\uacfc\ub2e4. \uc774 \uac1c\ub150\uc744 \uc774\ud574\ud558\uace0 \ub098\uba74 CASA\ub294 \ub2e8\uc21c\ud55c \uc790\uac00\ud3ec\uc2dd \uacbd\ub85c\uac00 \uc544\ub2c8\ub77c \uae30\uacc4\uc801 \uc7a5\ub825\uc744 \uc7a5\uae30\uc801\uc778 \uadfc\uc721 \uc801\uc751\uc73c\ub85c \uc5f0\uacb0\ud558\ub294 \ud558\ub098\uc758 \uc911\uc694\ud55c \uc5f0\uacb0\uace0\ub9ac<\/strong>\ub85c \ubcf4\uc774\uae30 \uc2dc\uc791\ud55c\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"

\uc800\ud56d\uc6b4\ub3d9\uc73c\ub85c \ub2e8\ubc31\uc9c8\uc774 \ubcc0\ud615\ub418\uba74 \uc774\ub97c \uac10\uc9c0\ud558\uace0 \uace8\ub77c\ub0b4\ub294 \uc138\ud3ec \ub0b4 \ud488\uc9c8\uad00\ub9ac \uc2dc\uc2a4\ud15c \uc791\ub3d9 FLNC \uc190\uc0c1 \u2192 BAG3\u00b7HSPB8 \uc911\uc2ec CASA \u2192 \uc720\ube44\ud034\ud2f4 \ud45c\uc9c0 \u2192 SQSTM1 \u2192 \uc624\ud1a0\ud30c\uace0\uc880 \u2192 \ub9ac\uc18c\uc880 \ubd84\ud574 \u2192 \uc0c8\ub85c\uc6b4 \uad6c\uc870 \ub2e8\ubc31\uc9c8 \uad50\uccb4 \uc6e8\uc774\ud2b8\ud2b8\ub808\uc774\ub2dd\uc5d0\uc11c \ud754\ud788 \uac15\uc870\ub418\ub294 \uac1c\ub150\uc740 \u2018\ub2e8\ubc31\uc9c8 \ud569\uc131\u2019\uc774\ub2e4. \uc6b4\ub3d9\uc73c\ub85c \uadfc\uc721\uc5d0 \uc790\uadf9\uc744 \uc8fc\uba74 \ub2e8\ubc31\uc9c8 \ud569\uc131\uc774 \uc99d\uac00\ud558\uace0, \uc7a5\uae30\uc801\uc73c\ub85c \uadfc\ube44\ub300\uc640 \uadfc\ub825 \ud5a5\uc0c1\uc774 \uc77c\uc5b4\ub09c\ub2e4\ub294 \uc124\uba85\uc774\ub2e4. \uadf8\ub7ec\ub098 \uadfc\uc721 \uc801\uc751\uc744 \uc774\ud574\ud558\ub824\uba74 […]<\/p>\n","protected":false},"author":401,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,40,42,16],"tags":[],"class_list":["post-1829","post","type-post","status-publish","format-standard","hentry","category-14","category-40","category-42","category-16"],"_links":{"self":[{"href":"https:\/\/rhanews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/1829","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rhanews.co.kr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rhanews.co.kr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rhanews.co.kr\/index.php?rest_route=\/wp\/v2\/users\/401"}],"replies":[{"embeddable":true,"href":"https:\/\/rhanews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1829"}],"version-history":[{"count":1,"href":"https:\/\/rhanews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/1829\/revisions"}],"predecessor-version":[{"id":1831,"href":"https:\/\/rhanews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/1829\/revisions\/1831"}],"wp:attachment":[{"href":"https:\/\/rhanews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rhanews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rhanews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}